Endocrine Abstracts

PRIMARA is the first observational study to describe the demographic and clinical profiles of adults with primary hyperparathyroidism (pHPT) receiving cinacalcet in daily clinics across European countries.Patients with pHPT aged ≥18 years without prior cinacalcet treatment were eligible. Initial cinacalcet dosage and subsequent dose changes were at the investigator’s discretion. Information on dosing, biochemistry and adverse drug reactions (A...

Objective: To compare 2 modalities of bolus-basal insulin therapy with aspart-detemir, according to the moment of administration of detemir (DET), before the lunch or bed-time, in type 1 diabetic patients with poor metabolic control.Methods: We conducted a prospective study of 40 type 1 diabetic patients, with poor metabolic control (HbAc 7–12%), randomized to receive treatment with 1 injection of DET before the lunch or bed-time and followed-up dur...

Childhood obesity has become a major health problem, which is coupled to different adverse outcomes and diseases. The escalating prevalence of child obesity parallels that of alterations in pubertal timing, also linked to higher disease burden later on life. Yet, the mechanisms underlying for this association remain unfolded. Ceramides, ubiquitous signaling molecules involved in numerous biological processes, have emerged as mediators of metabolic disorders and transmitters fo...

Introduction: Cardiovascular disease (CVD) is a health issue, worldwide, particularly in individuals with diabetes. The identification of CVD biomarkers can improve risk stratification. Sclerostin is a modulator of the Wnt/β-catenin signalling pathway in different tissues, and has recently been linked to vascular biology.Objectives: Our objective was to evaluate the relationship between circulating sclerostin levels and cardiovascular and non-cardio...

Introduction: Adrenal crisis is a life-threatening emergency, however, the relation between adrenal crisis and life-threatening arrhythmia is not known. We describe the case of a patient with adrenal crisis and arrhythmia with prolongation of QT interval.Case report: A 56-year-old woman was admitted to our hospital because of syncope. She reported having had similar episodes in the last year. She had no previous diagnoses and was not receiving any treatm...

Introduction: Osmotic demyelination syndrome (ODS) is a well described, potentially devastating consequence of rapid alterations in plasma osmolality, classically occurring secondary to the excessively rapid correction of chronic hyponatraemia. We describe a case of diabetes insipidus (DI) resulting in a Locked-in syndrome (LIS) caused by a rapidly developing severe hypernatremia.Case report: A 43-year-old woman was admitted to the Internal Medicine ward...

Background and aimsLifestyle modifications based on diet and exercise are common strategies for the treatment and prevention of obesity and related comorbidities. However, not all patients respond equally to similar weight loss intervention which compromise patient adherence. Strategies for predicting the individual response are required for improving intervention efficiency by personalized recommendations. microRNAs (miRNAs), small RNA particles which r...

ObjectiveTo study the possible relationship between adherence to the Mediterranean diet and the metabolic syndrome. Material and methods: Retrospective observational study of patients evaluated in a prebariatric surgery consultation between November 2017 and November 2019, who were given a questionnaire of adherence to a Mediterranean diet. Anthropometric and analytical parameters related to the metabolic syn...

IntroductionThe SARS-Coronavirus-2 pandemic affects 248 469 people with 28 341 deaths in Spain as of June 28, 2020. Severe infection is more prevalent in patients with advanced ages, cardiovascular risk factors (CVRF) and chronic diseases (diabetes mellitus, cardiovascular disease and asthma). Having diabetes implies vulnerability to serious complications and death from coronavirus; although, not all diabetics have the same level of risk. The oldest is p...

Introduction: Hypophosphatasia (HPP) is characterised by a deficiency of non-tissue-specific alkaline phosphatase. This results in abnormal mineralisation of bone tissue which predisposes to fragility fractures. Moreover, an affected muscle compartment could favour the risk of fracture. The aim was to evaluate the relationship between the bone and muscle compartment.Material and Methods: Cross-sectional study in adults with PPH. Demographic (age, sex), a...